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KMID : 0860920150170010025
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Journal of the Korean Association EMG-Electrodiagnostic Medicine
2015 Volume.17 No. 1 p.25 ~ p.30
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Aggravated Carpal Tunnel Syndrome after Paclitaxel Chemotherapy without Development of Periphearl Ployneurpathy - A Case Report -
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Do Hyun-Jung
Kim Hae-Rim
Kim Min-Wook
Jang Dae-Hyun
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Abstract
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Functionally disabling peripheral neuropathy is a major side effect of many chemotherapeutic agents. Chemotherapy (CTx) commonly induces distal, symmetric peripheral polyneuropathy (PPNP), for which there is no specific treatment. We report a case in which paclitaxel-based CTx did not induce PPNP but instead aggravated the pre-existing carpal tunnel syndrome (CTS), which improved after surgical decompression. Because subclinical entrapment neuropathy is not uncommon, we suggest evaluating the pre-existing neuropathy before starting CTx. If a focal entrapment neuropathy, including CTS, is found, patients should be warned of the possibilities of belated aggravation of such neuropathies with CTx, and if possible, regular follow-up with nerve conduction studies and needle electromyography should be performed for early diagnosis. Furthermore, because prompt surgical correction is likely to improve the cases of aggravated CTS and possibly other focal entrapment neuropathies, early diagnosis and immediate intervention will lead to better functional outcomes.
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KEYWORD
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carpal tunnel syndrome, paclitaxel, polyneuropathies
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